Amazon M-Tonic

120 capsules (650 mg each)

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A botanical formula which combines 8 plants used by the shamans of the rainforest and herbal practitioners in South America for male vigor, libido, and as specific tonics for men.* For more information on the individual ingredients in Amazon M-T-Tonic, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A herbal blend of muira puama, maca, suma, sarsaparilla, catuaba, chuchuhuasi, nettle, and jatoba. To prepare this natural remedy yourself: use two parts muira puama, two parts maca, and one part each of the remaining plants in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 10 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 1 to 1.5 grams 2-3 times daily. (1 gram is approximately 1 teaspoon by volume)

Contraindications: None.

Drug Interactions: May enhance the effect of high blood pressure medications.

Other Practitioner Observations: Several plants in this formula have been documented to reduce blood pressure. Individuals with low blood pressure should be monitored for this possible effect.

Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Muira puama (Ptychopetalum olacoides)
Figueiro, M., et al. "The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model." Phytomedicine. 2011 Feb 15;18(4):327-33.
Figueiro, M., et al. "Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama)." Phytomedicine. 2010 Oct;17(12):956-62.
Tang, W., et al. "Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides." Bioorg Med Chem Lett. 2009 Feb 1;19(3):882-6.
da Silva, A., et al. "MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic"." Psychopharmacology (Berl). 2009 Jan;202(1-3):165-72.
Tang, W., et al. "Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides." J Nat Prod. 2008 Oct;71(10):1760-3.
da Silva, A., et al. "Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama)." Physiol Behav. 2008 Sep 3;95(1-2):88-92.
Siqueira, I., et al. "Antioxidant activities of Ptychopetalum olacoides ("muirapuama") in mice brain." Phytomedicine. 2007 Nov;14(11):763-9.
da Silva, A. L., et al. "Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms." J. Ethnopharmacol. 2007 Feb; 109(3): 449-457.
da Silva, A. L., et al. “Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 199-203.
Siqueira, I. R., et al. “Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices.” Life Sci. 2004 Aug; 75(15): 1897-906.
Siqueira, I. R., et al. “Ptychopetalum olacoides, a traditional Amazonian "nerve tonic," possesses anticholinesterase activity.” Pharmacol. Biochem. Behav. 2003 Jun; 75(3): 645-50.
Siqueira, I. R., et al. “Psychopharamcological properties of Ptychopetalum olachoides Bentham (Olacaceae).” Pharmaceutical Biol. 1998; 36(5): 327–34.
Forgacs, P., et al. “Phytochemical and biological activity studies on 18 plants from French Guyana.” Plant Med. Phytother. 1983; 17(1): 22–32.
Dias Da Silva, Rodolpho. “Medicinal plants of Brazil. Botanical and pharmacognostic studies. Muira puama.” Rev. Bras. Med. Pharm. 1925; 1(1): 37–41.
Anti-stress effects of the "tonic" Ptychopetalum olacoides (Marapuama) in mice." Phytomedicine. 2010 Mar;17(3-4):248-53.
Piato, A., et al. "Antidepressant profile of Ptychopetalum olacoides Bentham (Marapuama) in mice." Phytother Res. 2009 Apr;23(4):519-24.
Piato, A., et al. "Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties." J Ethnopharmacol. 2008 Jul 23;118(2):300-4.
da Silva, A. L., et al. “Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama).” Phytother. Res. 2002; 16(3): 223-6.
Siqueira, I. R., et al. “Psychopharamcological properties of Ptychopetalum olachoides Bentham (Olacaceae).” Pharmaceutical Biol. 1998; 36(5): 327–34.

Maca (Lepidum meyenii)
Lopez-Fando, A., et al. “Lepidium peruvianum Chacon restores homeostasis impaired by restraint stress.” Phytother. Res. 2004; 18(6): 471-4.
Cicero, A. F., et al. “Hexanic maca extract improves rat sexual performance more effectively than methanolic and chloroformic maca extracts.” Andrologia. 2002; 34(3): 177–79.
Cicero, A. F., et al. “Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity.” J. Ethnopharmacol. 2001; 75(2–3): 225–29.
Zheng, B. L., et al. “Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats." Urology 2000; 55(4): 598–602.
Gonzales, G. F., et al. “Red maca (Lepidium meyenii) reduced prostate size in rats.” Reprod. Biol. Endocrinol. 2005; 3(1): 5.
Chung, F., et al. “Dose-response effects of Lepidium meyenii (Maca) aqueous extract on testicular function and weight of different organs in adult rats.” J. Ethnopharmacol. 2005 Apr; 98(1-2): 143-7.
Gonzales, G. F., et al. “Effect of Lepidium meyenii (maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men.” J. Endocrinol. 2003; 176(1): 163–68.
Gonzales, G. F., et al. “Effect of Lepidium meyenii (maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.” Andrologia. 2002; 34(6): 367–72.

Catuaba (Erythroxylum)
Kamden, J., et al. "Catuaba (Trichilia catigua) Prevents Against Oxidative Damage Induced by In Vitro Ischemia-Reperfusion in Rat Hippocampal Slices." Neurochem Res. 2012 Dec;37(12):2826-35.
Jaciana, S., et al. "Antimicrobial, Antiproliferative and Proapoptotic Activities of Extract, Fractions and Isolated Compounds from the Stem of Erythroxylum caatingae Plowman." Int J Mol Sci. 2012; 13(4): 4124–4140.
Viana, A., et al. " Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects" Evid Based Complement Alternat Med. 2011; 2011:
Vaz, Z. R., et al. “Analgesic effect of the herbal medicine Catuaba in thermal and chemical models of nociception in mice.” Phytother. Res. 1997; 11(2): 101–6.
Barbosa, N. R., et al. “Inhibition of platelet phospholipase A2 activity by catuaba extract suggests anti-inflammatory properties.” Phytother. Res. 2004; 18(11): 942-4.
Campos, M. M., et al. “Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms.” Psychopharmacology (Berl). 2005; 182(1): 45-53.

Suma (Pfaffia paniculata)
Oshima, M., et al. “Pfaffia paniculata-induced changes in plasma estradiol-17beta, progesterone and testosterone levels in mice.” J. Reprod. Dev. 2003 Apr; 49(2): 175-80.
Arletti, R., et al. “Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats." Psychopharmacology. 1999; 143(1): 15–9.
Matsumoto, I., “Beta-ecdysone from Pfaffia paniculata." Japanese patent no. 82/118,422. January 20, 1984.
de Oliveira, F. G., et al. “Contribution to the pharmacognostic study of Brazilian ginseng Pfaffia paniculata.” An. Farm. Quim. 1980; 20(1–2): 277–361.
Pinello, K. C., et al. “Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity.” Life Sci. 2005 Oct 6;
Mazzanti, G., et al. “Analgesic and anti-inflammatory action of Pfaffia paniculata (Martius) Kuntze." Phytother. Res. 1994; 8(7): 413-16.

Sarsaparilla (Smilax officinalis)
Hu, Y., et al. “A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models.” Brain Res. 2005 Oct; 1060(1-2): 26-39.
Bernardo, R. R., et al. “Steroidal saponins from Smilax officinalis.” Phytochemistry. 1996; 43(2): 465-9.
Chen, T., et al. “A new flavanone isolated from Rhizoma smilacis glabrae and the structural requirements for its derivatives for preventing immunological hepatocyte damage." Planta Med. 1999; 65(1): 56–9.
Rafatullah, S., et al. “Hepatoprotective and safety evaluation studies on sarsaparilla.” Int. J. Pharmacognosy 1991; 29: 296–301.
Chu, K. T., et al. “Smilaxin, a novel protein with immunostimulatory, antiproliferative, and HIV-1-reverse transcriptase inhibitory activities from fresh Smilax glabra rhizomes.” Biochem. Biophys. Res. Commun. 2005 Dec; 340(1): 118.

Chuchuhuasi (Maytenus krukovii, macrocarpa)
Nakagawa, H., et al. “Chemical constituents from the Colombian medicinal plant Maytenus laevis.J. Nat. Prod. 2004; 67(11): 1919-24.
Moreira, R. R., et al. “Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products.” Biol. Pharm. Bull. 2001; 24(2): 201-4.
Flemming, K. “Increase of phagocytosis activity by Maytenus laevis leaves and Scholler-Tornesch lignine (Porlisan).” Naturwissenschaften. 1965 Jun; 52(12):3 46-7.
Dicarlo F. J., et al. “Protection of mice against gram-positive bacteria with Maytenus laevis and other RES stimulants.” Proc. Soc. Exp. Biol. Med. 1964 May; 116:195-7.

Nettles (Urtica dioica)
Popa, G., et al. “Efficacy of a combined Sabal-urtica preparation in the symptomatic treatment of benign prostatic hyperplasia. Results of a placebo-controlled double-blind study.” MMW Fortschr. Med. 2005 Oct; 147 Suppl 3:103-8.
Lopatkin, N., et al. “Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms--a placebo-controlled, double-blind, multicenter trial.” World J. Urol. 2005 Jun; 23(2): 139-46.
Popa, G., et al. “Benign prostate syndrome: urinary tract symptoms can be eased with phytotherapy.” MMW Fortschr. Med. 2005 Aug; 147(33-34):42.
Schneider, T., et al. “Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months” Urologe A. 2004 Mar;43(3):302-6.
Durak, I., et al. “Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer.” Cancer Biol. Ther. 2004; 3(9): 855-7.
Melo, E. A., et al. “Evaluating the efficiency of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial.” Int. Braz. J. Urol. 2002 Sep-Oct; 28(5): 418-25.
Koch, E. “Extracts from fruits of saw palmetto (Sabal serrulata) and roots of stinging nettle (Urtica dioica): viable alternatives in the medical treatment of benign prostatic hyperplasia and associated lower urinary tracts symptoms.” Planta Med. 2001; 67: 489-500.
Sokeland, J. “Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome.” B. J. U. Int. 2000; 86(4): 439-42.
Schottner, M., et al. “Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).” Planta Med. 1997; 63(6): 529-32.
Lichius, J. J., et al. “The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse.” Planta Med. 1997; 63(4): 307-10.
Hryb, D. J., et al. “The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes.” Planta Med. 1995; 61(1): 31-2.
Koch E. and A. Biber. "Pharmacological effects of saw palmetto and urtica extracts for benign prostatic hyperplasia." Urologe 1994; 34(2): 90-95.
Krzeski, T., et al. “Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses.” Clin. Ther. 1993; 15(6): 1011-20.

Jatobá (Hymenaea courbaril)
Abdel-Kader, M., et al. “Isolation and absolute configuration of ent-Halimane diterpenoids from Hymenaea courbaril from the Suriname rain forest.” J. Nat. Prod. 2002; 65(1): 11-5.
Braga, F. C., et al. “Screening Brazilian plant species for in vitro inhibition of 5-lipoxygenase.” Phytomedicine. 2000; 6(6): 447-52.
Verpoorte, R., et al. "Medicinal plants of Surinam. IV. Antimicrobial activity of some medicinal plants." J. Ethnopharmacol. 1987; 21(3): 315-18.
Rahalison, L., et al. "Screening for antifungal activity of Panamanian plants." Inst. J. Pharmacog. 1993; 31(1): 68-76.

*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 12-27-2012