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Clavilla has a long history of use in the Amazon rainforest for all types of infections.* Chemical analysis of clavillia shows that it is rich in many active compounds including triterpenes, proteins, flavonoids, alkaloids, and steroids. Of particular interest to researchers is a group of amino acid-based proteins, called mirabilis antiviral proteins (MAPs). These chemicals have shown specific antiviral and antifungal actions in laboratory research.* For more information about clavillia (Mirabilis jalapa), please refer to the Database File for Clavillia in the Tropical Plant Database. To see pictures of clavillia click here. Check out the new Discussion Forums to see if anyone is talking about how they are using this natural rainforest remedy.
Traditional Uses:* as a broad-spectrum antimicrobial for bacterial, fungal, and viral infections; for Candida and yeast infections; as a bowel cleanser and laxative; for skin problems (eczema, dermatitis, acne, rashes, liver spots, skin fungi, ringworm); for vaginal discharge, infections, and sexually transmitted diseases
Suggested Use:This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1/2 cup dosages, twice daily. For more complete instructions on preparing herbal infusions see the Methods for Preparing Herbal Remedies Page.
Drug Interactions: None reported.
- The seeds of the plant contain neurotoxic chemicals and should not be ingested.
- Chemicals found in clavillia have been documented to have abortive actions. Clavillia itself has been documented with a mild uterine stimulant effect, therefore; its use during pregnancy is contraindicated.
Third-Party Published Research*
All available third-party research on clavillia can be found at PubMed. A partial listing of the published research on clavillia is shown below:
Antimicrobial Actions (virus, bacteria, fungi, and yeast):
Michalet, S., "N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors." Bioorg. Med. Chem. Lett. 2007 Mar; 17(6): 1755-8.
Bolognesi, A. et al. “Ribosome-inactivating and adenine polynucleotide glycosylase activities in Mirabilis jalapa L. tissues.” J. Biol. Chem. 2002; 277(16) 13709–16.
Yang, S. W., et al. “Three new phenolic compounds from a manipulated plant cell culture, Mirabilis jalapa.” J. Nat. Prod. 2001; 64(3): 313–17.
Vivanco, J. M., et al. “Characterization of two novel type 1 ribosome-inactivating proteins from the storage roots of the Andean crop Mirabilis expansa.” Plant Physiol. 1999; 119(4): 1447–56.
Dimayuga, R. E., et al. ”Antimicrobial activity of medicinal plants from Baja California Sur (Mexico).” Pharmaceutical Biol. 1998; 36(1): 33–43.
De Bolle, M. F., et al. “Antimicrobial peptides from Mirabilis jalapa and Amarantus caudatus: expression, processing, localization and biological activity in transgenic tobacco.” Plant Mol. Biol. 1996; 31(5): 993–1008.
Kataoka, J., et al. “Adenine depurination and inactivation of plant ribosomes by an antiviral protein of Mirabilis jalapa (MAP).” Plant Mol. Biol. 1992; 20(6): 111–19.
Wong, R. N., et al. “Characterization of Mirabilis antiviral protein—a ribosome inactivating protein from Mirabilis jalapa L.” Biochem. Int. 1992; 28(4): 585–93.
Cammue, B. P., et al. “Isolation and characterization of a novel class of plant antimicrobial peptides from Mirabilis jalapa L. seeds.” J. Biol. Chem. 1992; 267(4): 2228–33.
Caceres, A., et al. “Plants used in Guatemala for the treatment of dermatophytic infections. Screening for antimycotic activity of 44 plant extracts.” J. Ethnophamacol. 1991; 31(3): 263–76.
Kusamba, C., et al. “Antibacterial activity of Mirabilis jalapa seed powder.” J. Ethnopharmacol. 1991; 35(2): 197–99.
Caceres, A., et al. “Screening of antimicrobial activity of plants popularly used in Guatemala for the treatment of dermatomucosal diseases.” J. Ethnopharmacol. 1987; 20(3): 223–37.
Antispasmodic & Anti-inflammatory Actions:
Singh, M., et al. "Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves." Pharmacognosy Res. 2010 Nov;2(6):364-7.
Aoki, K., et al. "Pharmacological study of antispasmodic activity of Mirabilis jalapa Linn flowers." J. Ethnopharmacol. 2008 Feb; 116(1): 96-101.
Dhar, M. L., et al. “Screening of Indian plants for biological activity: Part I.” Indian J. Exp. Biol. 1968; 6: 232–47.
Walker, C., et al. "Antinociceptive activity of Mirabilis jalapa in mice." J. Ethnopharmacol. 2008 Nov; 120(2): 169-75.
Anti-Diabetic & Cholesterol-lowering Actions:
Zhou, J., et al. "Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract of Mirabilis jalapa L. Root on Normal and Diabetic Mice." Evid Based Complement Alternat Med. 2012;2012:257374.
Zhou, J., et al. "Experimental diabetes treated with trigonelline: effect on beta cell and pancreatic oxidative parameters." Fundam Clin Pharmacol. 2011 Dec 16.
Ghule, A., et al. "Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats."
Int Immunopharmacol. 2012 Dec;14(4):740-8.
Zhou, J., et al. "Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease." Curr Med Chem. 2012;19(21):3523-31.
Maxia, A., et al. "Inhibition of histamine mediated responses by Mirabilis jalapa: confirming traditional claims made about antiallergic and antiasthmatic activity." Nat Prod Res. 2010 Nov;24(18):1681-6.
Plant Chemicals Identified:
Lai, G., et al. "Studies on chemical constituents from roots of Mirabilis jalapa." Zhongguo. Zhong. Yao. Za. Zhi. 2008 Jan; 33(1): 42-6.
Wei, Y., et al. "Studies on chemical constituents from the root of Mirablis jalapa." Zhongguo. Zhong. Yao. Za. Zhi. 2003; 28(12): 1151-2.
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Last updated 12-17-2012