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Canchalagua is employed as an herbal remedy in the Peruvian Amazon for kidney, liver, and renal problems, malaria, diabetes, allergies, yeast infections, prostate inflammation, digestive disorders and intestinal gas, rheumatism, and various skin conditions such as acne, dermatitis, and eczema.* For more information about canchalagua (Schkuhria pinnata), please refer to the Database File for Canchalagua. To see photographs of canchalagua click here.
Traditional Uses:* as a blood cleanser; used internally and externally for pimples, blackheads, and acne; as a diuretic and antimicrobial for urinary tract problems; for skin problems (eczema, dermatitis, etc.); for malaria
Suggested Use: This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1 cup dosages, 2-3 times daily. For more complete instrutions on preparing tinctures see the Methods for Preparing Herbal Remedies Page.
Contraindications: None reported
Drug Interactions: None reported.
Third-Party Published Research*
All available third-party research on canchalagua can be found at PubMed.
A partial listing of the published research on canchalagua is shown below:
Kassuya, C., et al. "Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)." J. Ethnopharmacol. 2009 Jul; 124(3): 369-76.
Lim, H., et al. "Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum." Biol. Pharm. Bull. 2008; 31(11): 2063-7.
Pae, H., et al. "Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages." Inflamm. Res. 2007; 56(12): 520-6.
Nam, N. H. "Naturally occurring NF-KappaB inhibitors." Mini. Rev. Med. Chem. 2006; 6(8): 945-51.
De Marino, S., et al. "New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production." Planta Med. 2005; 71(8): 706-10.
Korhonen, R., et al. "Nitric oxide production and signaling in inflammation." Curr. Drug Targets Inflamm. Allergy. 2005 Aug; 4(4): 471-9.
Weimann, C., et al. "Spasmolytic effects of Baccharis conferta and some of its constituents." J. Pharm. Pharmacol. 2002; 54(1): 99-104.
Antimicrobial Actions (mold, fungi, yeast, bacteria, mycobacteria):
Bussmann, R., et al. " Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies." J Ethnopharmacol. 2010 October 28; 132(1): 101–108.
Wagate, C., et al. "Screening of some Kenyan medicinal plants for antibacterial activity." Phytother. Res. 2010; 24(1): 150-3.
Luna-Herrera, J., et al. "Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp." J. Antimicrob. Chemother. 2007; 59(3): 548-52.
Quiroga, E. N., et al. "Screening antifungal activities of selected medicinal plants." J. Ethnopharmacol. 2001; 74(1): 89-96.
Tanaguchi, M., "Screening of East African plants for antimicrobial activity. I." Chem. Pharm. Bul. 1978: 2910-2913.
Perez, C., et al. "Inhibition of Pseudomonas aeruginosa by Argentinean medicinal plants." Fitoterapia. 1994; 65(2): 169-172.
Anesini, C., et al. "Screening of plants used in Argentine folk medicine for antimicrobial activity." J. Ethnopharmacol. 1993; 39(2): 119-128.
Johns, T., et al. "Anti-giardial activity of gastrointestinal remedies of the Luo of East Africa." J. Ethnopharmacol. 1995; 46(1): 17-23.
Perez, C., et al. "In vitro antibacterial activity of Argentine folk medicinal plants against Salmonella typhi." J. Ethnopharmacol. 1994; 44(1): 41-46.
Hypoglycemic and Cholesterol Lowering Actions:
Deutschländer, M., et al. "Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes." J. Ethnopharmacol. 2009 Jul 30;124(3):619-24.
Eliza, J., et al. "Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats." Chem. Biol. Interact. 2009 May; 179(2-3): 329-34.
Cytotoxic & Anticancerous Actions:
Choi, J., et al. "Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation." Biol. Pharm. Bull. 2009; 32(10): 1803-8.
Kim, S., et al. "Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds." Br. J. Pharmacol. 2008 Nov; 155(6): 814-25.
Robinson, A., et al. "A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study." Bioorg. Med. Chem. Lett. 2008 Jul; 18(14):4015-7.
Kanno, S., et al. "Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells." Biol. Pharm. Bull. 2008; 31(5): 1024-8.
Choi, J., et al. "Melanogenesis inhibitory compounds from Saussureae Radix." Arch. Pharm. Res. 2008; 31(3): 294-9.
Liver Protective Actions:
Yoo, Y., et al. "Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism." Biol. Pharm. Bull. 2008; 31(4): 760-4.
Muthaura, C., et al. "Antimalarial activity of some plants traditionally used in Meru district of Kenya." Phytother. Res. 2007; 21(9):860-7.
Munoz, V., et al. "A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part III. Evaluation of the antimalarial activity of plants used by Altenos Indians." J. Ethnopharmacol. 2000; 71(1/2): 123-131.
Bussman, R., et al. "Toxicity of medicinal plants used in traditional medicine in Northern Peru." J Ethnopharmacol. 2011 September 1; 137(1): 121–140.
Ganzer, U., et al. "Schkuhripinnatolides, unusual sesquiterpene lactones from Schkuhria pinnata." Phytochemistry. 1990; 29(2): 535-539.
Pacciaroni, A. D. V., et al. "Sesquiterpene lactones from Schkuhria pinnata." Phytochemistry. 1995; 39(1): 127-131.
Bohlmann, F., et al. "Naturally occurring terpene derivatives. 102. New nerol derivatives and a new class of dihydrocinnamyl alcohol derivates from Schkuhria species." Phytochemistry. 1977: 780-781.
Bohlmann, F., et al. Naturally occurring terpene derivatives. Part 373. A helangiolide from Schkuhria pinnata." Phytochemistry. 1981: 2431-2432.
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Last updated 12-17-2012